Nature Reviews Molecular Cell Biology 16, 417 (2015)
Swiss army knives: non-canonical functions of nuclear Drosha and Dicer
Kaspar Burger, Monika Gullerova.
The RNase III enzymes Drosha and Dicer are essential for the production of small non-coding RNAs (ncRNAs). In canonical RNAi, microRNAs (miRNAs) regulate gene expression by post-transcriptional gene silencing. In non-canonical RNAi, nuclear RNAi factors generate small ncRNAs that are essential for transcriptional gene silencing.