PNAS

Fundamental limits on the accuracy of demographic inference based on the sample frequency spectrum [Evolution]

J. Terhorst, Y. S. Song.
The sample frequency spectrum (SFS) of DNA sequences from a collection of individuals is a summary statistic that is commonly used for parametric inference in population genetics. Despite the popularity of SFS-based inference methods, little is currently known about the information theoretic limit on the estimation accuracy as a function...