PNAS

Inference of transcriptional regulation in cancers [Biophysics and Computational Biology]

P. Jiang, M. L. Freedman, J. S. Liu, X. S. Liu.
Despite the rapid accumulation of tumor-profiling data and transcription factor (TF) ChIP-seq profiles, efforts integrating TF binding with the tumor-profiling data to understand how TFs regulate tumor gene expression are still limited. To systematically search for cancer-associated TFs, we comprehensively integrated 686 ENCODE ChIP-seq profiles representing 150 TFs with 7484...