PNAS

Single-molecule analysis reveals widespread structural variation in multiple myeloma [Applied Biological Sciences]

A. Gupta, M. Place, S. Goldstein, D. Sarkar, S. Zhou, K. Potamousis, J. Kim, C. Flanagan, Y. Li, M. A. Newton, N. S. Callander, P. Hematti, E. H. Bresnick, J. Ma, F. Asimakopoulos, D. C. Schwartz.
Multiple myeloma (MM), a malignancy of plasma cells, is characterized by widespread genomic heterogeneity and, consequently, differences in disease progression and drug response. Although recent large-scale sequencing studies have greatly improved our understanding of MM genomes, our knowledge about genomic structural variation in MM is attenuated due to the limitations...