PNAS

Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages [Microbiology]

F. Graziano, M. Desdouits, L. Garzetti, P. Podini, M. Alfano, A. Rubartelli, R. Furlan, P. Benaroch, G. Poli.
HIV type 1 (HIV-1) infects CD4+ T lymphocytes and tissue macrophages. Infected macrophages differ from T cells in terms of decreased to absent cytopathicity and for active accumulation of new progeny HIV-1 virions in virus-containing compartments (VCC). For these reasons, infected macrophages are believed to act as “Trojan horses” carrying...