Nature
The core spliceosome as target and effector of non-canonical ATM signalling
Maria Tresini, Daniël O. Warmerdam, Petros Kolovos, Loes Snijder, Mischa G. Vrouwe, Jeroen A. A. Demmers, Wilfred F. J. van IJcken, Frank G. Grosveld, René H. Medema, Jan H. J. Hoeijmakers, Leon H. F. Mullenders, Wim Vermeulen, Jurgen A. Marteijn.
Transcription-blocking DNA lesions result in chromatin displacement of core spliceosomes containing U2 and U5 snRNPs; consequently, R-loops containing the nascent transcript are formed, which activate ATM in a feed-forward fashion to influence spliceosome dynamics and alternative splicing.