Nature Biotechnology
A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides
Joel M Chick, Deepak Kolippakkam, David P Nusinow, Bo Zhai, Ramin Rad, Edward L Huttlin, Steven P Gygi.
In shotgun proteomics experiments, modified peptides account for a large part of the unassigned spectra and can be identified using ultra-tolerant database searches.