PNAS

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens [Immunology and Inflammation]

C. N. Casson, J. Yu, V. M. Reyes, F. O. Taschuk, A. Yadav, A. M. Copenhaver, H. T. Nguyen, R. G. Collman, S. Shin.
Inflammasomes are critical for host defense against bacterial pathogens. In murine macrophages infected by gram-negative bacteria, the canonical inflammasome activates caspase-1 to mediate pyroptotic cell death and release of IL-1 family cytokines. Additionally, a noncanonical inflammasome controlled by caspase-11 induces cell death and IL-1 release. However, humans do not encode...