PNAS

Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes [Developmental Biology]

K. T. Kuppusamy, D. C. Jones, H. Sperber, A. Madan, K. A. Fischer, M. L. Rodriguez, L. Pabon, W.-Z. Zhu, N. L. Tulloch, X. Yang, N. J. Sniadecki, M. A. Laflamme, W. L. Ruzzo, C. E. Murry, H. Ruohola-Baker.
In metazoans, transition from fetal to adult heart is accompanied by a switch in energy metabolism-glycolysis to fatty acid oxidation. The molecular factors regulating this metabolic switch remain largely unexplored. We first demonstrate that the molecular signatures in 1-year (y) matured human embryonic stem cell-derived cardiomyocytes (hESC-CMs) are similar to...