Nature Methods

Plasmodium falciparum genetic crosses in a humanized mouse model

Ashley M Vaughan, Richard S Pinapati, Ian H Cheeseman, Nelly Camargo, Matthew Fishbaugher, Lisa A Checkley, Shalini Nair, Carolyn A Hutyra, François H Nosten, Timothy J C Anderson, Michael T Ferdig, Stefan H I Kappe.
A human-liver chimeric mouse supports the growth of recombinant Plasmodium falciparum progeny, enabling easy analysis of genetic crosses between parasite strains.