Nature Methods
A microfluidic device for label-free, physical capture of circulating tumor cell clusters
A Fatih Sarioglu, Nicola Aceto, Nikola Kojic, Maria C Donaldson, Mahnaz Zeinali, Bashar Hamza, Amanda Engstrom, Huili Zhu, Tilak K Sundaresan, David T Miyamoto, Xi Luo, Aditya Bardia, Ben S Wittner, Sridhar Ramaswamy, Toshi Shioda, David T Ting, Shannon L Stott, Ravi Kapur, Shyamala Maheswaran, Daniel A Haber, Mehmet Toner.
The Cluster-Chip provides highly efficient and gentle capture of circulating tumor cell clusters from milliliters of unprocessed whole blood, making it possible to study how these clusters contribute to metastasis.